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Japanese

CEREBROSPINAL FLUID ABSORPTION INTO LYMPHATIC SYSTEM IN CONDITION OF INCREASED INTRACRANIAL PRESSURE Yoshio Asano 1 , Michiaki Hasuo 1 , Masaharu Teraoka 1 , Masahiro Furuse 1 , Naoki Kageyama 1 1Department of Neurosurgery, Nagoya University School of Medicine pp.673-678
Published Date 1981/7/1
DOI https://doi.org/10.11477/mf.1406204789
  • Abstract
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Dynamics of cerebrospinal fluid (CSF) absorption into cervical lymphatic flow was studied in 31 mongrel adult dogs in condition of normal and increased intracranial pressure (ICP). The experi-ment was composed of two different investigations ; observation on volume changes in cervical lymph outflow (Experiment I) and simultaneous radio-isotope counting in systematic blood, CSF and lymphatic fluid (Experiment II).

Both cervical lymph ducts were cannulated under intravenous pentobarbital anesthesia and the out-flow volume of lymphatic fluid was measured every 30 minutes. In Experiment I, levels of ICP were controlled by continuous infusion of artificial CSF through the lumbar subarachnoid space at the pressure ranges of 300 and 700mmH2O. Compared to the control volume of 18.1+2.0μl/min, cervicallymphatic fluid increased as the response to loaded ICP levels, being approximately 2.3 and 5 folds at the respective pressure ranges of 300 and 700mmH2O.

In Experiment II, 99mTc-DTPA (lmCi) was ad-ministered intrathecally through the cisterna magna and the changes in radioactivity were measured with the samples of venous blood and CSF, as well as of lymphatic fluid, every 30 minutes through the experiment. ICP was controlled by cisternal infusion at the same pressure levels as those in Experiment I. In contrast to the constant RI levels in cervical lymphatic fluid at normal pressure state, radioactivity in both lymphatic fluid and venous blood consistently increased during the periods of 30 to 210 minutes in the condition of raised ICP. In addition, radioactivity ratio of cervical lymphatic fluid to systematic venous blood also elevated in proportion to the loaded ICP levels and experi-mental time courses.

From these results, it is concluded that a part of CSF can be shifted into lymphatic channels under the condition of increased ICP and that shifted fluid is mainly derived from CSF space. When ICP is raised, the above mentioned CSF absorption into lymphatic system may play an important role to get CSF out from the cranial cavity.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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