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Brain and Nerve No to Shinkei Volume 30, Issue 9 （September 1978）

Brain and Nerve 脳と神経 30巻9号（1978年9月発行）

Japanese English

原著

¹³³Xeによる脳のFunctional Imagingに関する検討 STUDY OF FUNCTIONAL IMAGING OF REGIONAL CEREBRAL BLOOD FLOW BASED ON HEIGHT/AREA METHOD 山本義介 ¹ , 和賀志郎 ¹ , 小島精 ¹ , 坂倉允 ¹ , 前田寿登 ² , 中川毅 ² Yoshisuke Yamamoto ¹ , Shiro Waga ¹ , Tadashi Kojima ¹ , Makoto Sakakura ¹ , Hisato Maeda ² , Tsuyoshi Nakagawa ² ¹三重大学医学部脳神経外科 ²三重大学医学部放射線科 ¹Department of Nurosurgery, Mie University Medical School ²Department of Radiology, Mie University Medical School pp.995-1000

発行日 1978年9月1日 Published Date 1978/9/1

DOI https://doi.org/10.11477/mf.1406204305

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Abstract 文献概要
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I．はじめに

　これまで脳血流量に関する種々の測定方法が開発されてきたが，そのなかでも放射性希ガスによる局所脳循環血流量の測定は，Ingvar,Lassen以来，著しく進歩し，その臨床的意義について数多くの報告がなされている。しかしながら，シンチレーション検出器を用いて，局所脳血流量（rCBF）を測定するこれまでの方法は，検出器の数に限度があり小さい範囲で脳全領域のrCBF分布を得ることは困難である。

　最近，シンチカメラ，およびデータ処理装置または，オートフルオロスコープを用いて，単位領域ごとのrCBFを求め，脳全領域のrCBF分布を得る報告がなされている^2,11〜13）。

Since Ingver and Lassen measured regional cere-bral blood flow (rCBF) first in 1963, measurement of rCBF and its clinical application have widely been performed in the world.

In this paper the authors show practical value of the brain functional imaging of rCBF₁₀ measured by Height/Area method using ¹³³Xe.

The joint camera-computer system used consists of the GCA-202 scinticamera and the DAP-5000N computer system. Following internal carotid in-jection of 3-5 mCi of ¹³³Xe, 5second frames of data on a 64×64 matrix are obtained for a period of 14.5 minutes, utilizing the on-line computer system. The method is able to make a functional image of rCBF₁₀ by means of subtracting some amounts of rCBF₁₀ from the original rCBF₁₀ and the affected areas become more clear in photographs. For ex-ample, when the maximum rCBF₁₀ is 41 ml/100gr/ min and the average rCBF₁₀ is 21 ml/100gr/min, the areas where rCBF₁₀ is below 10ml/100gr/min are neglected and showed on the photographs. This method can clearly show the areas with decreased rCBF and is routinely used in our department in cases with cerebral vascular disease.

In this paper the authors represent typical cases with cerebral infarction, Neuro-Behcet and arterio-venous malformation (AVM).

Functional image of rCBF₁₀ in a case with cere-bral infarction clearly showed the areas with de-creased rCBF₁₀ and that of a case with AVM demon-strated that rCBF₁₀ was normalized near the region of the AVM after total removal where rCBF had been abnormally high. Functional image in a case with Neuro-Behçet syndrome immediately after ischemic insult revealed remarkably increased areas of rCBF₁₀ where cerebral angiography also showed capillary blush and early filling veins.

Functional imaging of rCBF is very reliable method and clear at a glance for detecting the lesion and effects of treatment in cerebral vascular disease.