雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

THE EFFECT OF MK-486 ALONE ON PARKINSONISM:STUDIES ON CLINICAL SYMPTOMS AND CHANGES OF CATECHOLAMINE CONCENTRATIONS IN THE BLOOD, URINE, AND CEREBROSPINAL FLUID Hideo Tohgi 1 , Makoto Ogawa 1 1Department of Neurology Tokyo Metropolitan Geriatric Hospital pp.205-213
Published Date 1977/2/1
DOI https://doi.org/10.11477/mf.1406204025
  • Abstract
  • Look Inside

The purpose of this paper is to report the effect of MK-486 alone on the clinical symptoms of Parkinsonism, and on the concentrations of catecholamines and their metabolites in the blood, urine, and cerebrospinal fluid. The materials con-sisted of 14 cases with Parkinsonism, ranging from 60 to 87 years of age. In patients who had received L-dopa, trihexyphenidil hydrochloride, phenothia-zines, or reserpine, or combinations of these, the drugs were discontinued for one week before the study. The results were as follows.

1) In 2 cases MK-486 was administered alone at the dose of 60 mg for 3 days and then 150 mg for 3 days, and compared with 2 cases administered placebo. There was no appreciable effect on the clinical symptoms of Parkinsonism. After MK-486, only a trace of DOPA and dopamine was detectable in the blood. Changes in the urinary concentrations of DOPA, dopamine, and HVA showed no re-markable tendency.

2) In 10 cases MK-486 was administered alone 75 mg for 3 days and then 150 mg for 4 days. There was no improvement in the symptoms of Parkinsonism. Measurements of catecholamines in the cerebrospinal fluid revealed that 6 showed an increase of DOPA, 5 showed an increase of dopamine, while in 8 cases HVA was decreased. Following combined administration of MK-486 and L-dopa at the dose of 60 mg and 750 mg respectively for one week, all cases showed an increase of DOPA and 7 cases showed an increase of dopamine and HVA in the cerebrospinal fluid.

It was concluded that administration of MK-486 alone was ineffective in the treatment of Parkinsonism.

The reasons for the discrepancy between the lack of improvement in the clinical symptoms and the elevation of CSF catecholamines following admin-istration of MK-486 alone were discussed.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

関連文献

もっと見る

文献を共有