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Japanese

A BIOPSY CASE OF NEUROPATHY ACCOMPANIED BY ACUTE RENAL INSUFFICIENCY DUE TO BROMATE Motonori Deshimaru , Taihei Miyakawa , Shiro Sumiyoshi , Yoshio Nomura pp.807-814
Published Date 1976/8/1
DOI https://doi.org/10.11477/mf.1406203929
  • Abstract
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A case of 21 year old male with neuropathy caused by renal insufficiency was present. He had taken bromate (mixed powder of potassium bromateand sodium bromate) for the purpose of suicide and suffered from acute renal insuffidiency and hard of hearing. Renal dysfunction improved gradually by peritoneal dialysis and hemodialysis. However, on the 32th day after the onset, burning pain appeared in the bilateral feets. Following this, he began to complain of the disturbances of superficial and deep sensory below the ankle jerks and the weakness of his toes. Considerring the clinical features, we supposed that the disturbance of the peripheral nerve was caused by uremia due to taking bromate. N. suralis was biopsied on the 80th day after the onset and examined electron microscopically. Electroscopical findings was asfollows. Degeneration of the Schwann cells and irregularity or destruction of the myelin sheaths were observed. The axoplasm of the myelinated nerve fiber were relatively preserved as compared with the changes of the myelin sheaths. In the unmyelinated nerve fibers, cavity formations were observed. The findings of regeneration were not observed. From the electron microscopical findings, we speculate that the changes of the Schwann cells and the myelin sheaths are primary resulting from the disturbance of the metabolism of the Schwann cells. We speculate that anemia and hypoproteine-mia caused by bromate disturbed regeneration.


Copyright © 1976, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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