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Japanese

HISTOPATHOLOGICAL CHANGES OF A NERVE AND MUSCLE BIOPSY OF A CASE OF FAMILIAL PRIMARY AMYLOIDOSIS: MECHANISM OF AMYLOID PRODUCTION Motonori Deshimaru 1 , Taihei Miyakawa 1 , Shiro Sumiyoshi 2 , Eiichi Murayama 2 , Seijun Tatetsu 2 1Department of Neurology, Toxicology Institute, Kumamoto University, School of Medicine 2Department of Neuropsychiatry, Kumamoto University, School of Medicine pp.661-666
Published Date 1976/7/1
DOI https://doi.org/10.11477/mf.1406203908
  • Abstract
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T. I., a male aged 38, had a hereditary primary amyloidosis over four generation in his family history. He had peripheral neuropathy with dis-sociated sensory disturbances in the lower limbs, impotence, gastrointerstial dysfunction and ortho-static hypotention.

N. suralis and M. quadriceps femoralis taken from him were examined by light and electron micro-scopy. N. suralis contained a lot of amyloids re-acting with congo-red in the nerve fibres. Amyloid fibrils were remarkably observed around the blood vessels. They were continuous with the basement membrane of the endotherial cells. A few deposites were observed around the Schwann cell and fibro-blasts. In M. quadriceps femoralis, amyloid like fibrils were noted in the perivascular spaces. Es-pecially, a great deal of amyloid fibrils were con-tinuous with the basement menbranes. From this finding, it might be speculated that the basement membrane may play an important role in the pro-duction of amyloid fibrils.


Copyright © 1976, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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