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DISC-ELECTROPHORESIS IN ACRYLAMIDE GEL OF CEREBROSPINAL FLUID PROTEINS ANALYSIS OF NORMAL CSF PROTEINS AND CSF PROTEINS OBTAINED FOR PNEUMOENCEPHALOGRAPHY Hidenori Kawakita 1 , Taiji Murakami 1 , Noriyuki Yamauchi 1 1Department of Neuropsychiatry, Tokyo Medical College pp.319-324
Published Date 1974/3/1
DOI https://doi.org/10.11477/mf.1406203515
  • Abstract
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1. Analysis of 47 normal cerebrospinal fluidproteins was carried out by DISC-electrophoresis.The mean value of relative concentration of eachprotein fraction in normal cerebrospinal fluid wasas follow: Pr: 7. 9%, Alb: 53. 3%, aL.: 3.4%, a':5.5%, Tr:9.4%, β': 4.2%, γ': 13.6%, Sa2: 2. 8%.

2. The correlation of the electrophoretic fractionsbetween cellulose acetate-electrophoresis and DISCelectrophoresis was proned and compared withnormal serum fractions by DISC-electrophoresis.

3. In the pherograms obtained at the time ofspinal tap for pneumoencephalograpy of 27 psy-chiatric or neurologic disorders, Pr increased gra-dually, Alb decreased gradually, aL, showed lowvalue, a' increased and ,β' (τ fraction) increasedgradually, from the initial portion to the final.The increased concentration of β-globulin by cel-lulose acetate or paper electrophoresis was due to the increased concentration of τ-fraction (β') than transferrin.

4. Abnormal cases of prealbumin were shown and origin of the proteins in cerebrospinal fluid was shortly discussed.


Copyright © 1974, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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