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Brain and Nerve No to Shinkei Volume 33, Issue 10 （October 1981）

Brain and Nerve 脳と神経 33巻10号（1981年10月発行）

Japanese English

原著

Disc電気泳動法による脳腫瘍髄液蛋白分画—病理所見との関連について DISC ELECTROPHORETIC PROTEIN FRACTIONS OF CEREBROSPINAL FLUID IN BRAIN TUMOR : WITH REGARD TO PATHOLOGICAL FINDING 河北英詮 ¹ , 手塚隆夫 ¹ , 黒羽根革躬 ¹ , 田島賢一 ² Hidenori Kawakita ¹ , Takao Tezuka ¹ , Kakumi Kurobane ¹ , Kenichi Tazima ² ¹東京医科大学精神医学教室 ²東京医科大学脳神経外科教室 ¹Department of Neuropsychiatry Tokyo Medical College ²Department of Neurosurgery, Tokyo Medical College pp.1021-1030

発行日 1981年10月1日 Published Date 1981/10/1

DOI https://doi.org/10.11477/mf.1406204833

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Abstract 文献概要
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緒言

　ポリアクリルアミド・ゲルを支持体とするDisc電気泳動法は，優れた蛋白分離と再現性があり，かつ髄液の濃縮操作を要せず，しかも微量の試料で行えることは，髄液蛋白分画法としてきわめて好都合である。先に100例の脳腫瘍の髄液蛋白分画について報告した^9）が，今回は合計100試料，50例の脳腫瘍の手術例について病理組織診断，大きさ，発生部位などとの関連について報告する。

Disc electrophoresis on acrylamide gel was carried out on cerebrospinal fluid protein of 100 samples taken from 50 cases of brain tumor. The results were concluded as follow.

1) The electrophoretic pattern revealed the dis-turbance of blood cerebrospinal fluid barrier in 58% which consisted of mixed type 21%, albumin type 26%, m+a type 3% and prealbumin decreased type 8%. Another electrophoretic patterns were 13% in γ-globulin type, 2% in prealbumin increased type, 5% in concentration type, 5% in miscellaneous type and 15% in normal type.

2) Abnormality of the electrophoresis were as follow from severe to slight grade. ① acoustic neurinoma in cerebellopontine region, ② gliomaadhered and invaded into the meninges, ③ menin-gioma, ④ craniopharyngioma in hypothalamic region, ⑤ glioma invaded into or in ventricle ⑥ glioma included in cerebral parenchyma.

3) Electrophoretic abnormality was somewhat higher in the cases of malignant glioblastoma than in the cases of benign astrocytoma in the cerebral. In the gliomas in the cerebral parenchyma, electro-phoretic abnormality was highly demonstrated in the glioma adhered or invaded into the meninges and was moderately demonstrated in the glioma into or in the ventricle and also was slightly found in the glioma included in cerebral parenchyma.

4) No distinct correlation was found between the appearance of abnormal electrophoresis and the size of tumor. The abnormality of electrophoresis was lower in the cases of capsulated tumor than in the those of the tumor with cystic formation and also was somewhat lower in the postoperative cases than in the pre-operative cases.

5) It was shortly discussed that the electropho-retic abnormality has in particular been concerned with the relationship between the anatomical site of the lesion and the C.S.F. pathway system rather than the nature of tumors.