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EXPERIMENTAL STUDY ON CEREBRAL VASOSPASM: ESPECIALLY ON POSTSPASTIC BIPHASIC VASODILATATION Tomio Ohta 1 , Masahiro Chokyu 1 , Shuro Nishimura 1 1Department of Neurosurgery, Osaka City University Medical School pp.427-435
Published Date 1972/4/1
DOI https://doi.org/10.11477/mf.1406203093
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Experimental spasm has been produced by localapplication of one to 2. 5% barium chloride solution to the rat's basilar artery and its branches. They have been reduced to about a third of their original width. Any difference has not been recognized regarding the grade of the spasm between the basilar artery and its branches. Different patterns of vasospasm have been observed similar to the angiographic demonstration of the vasospasm after the rupture of intracranial aneurysms. This means that there is a difference of vascular reactivity in the different parts of one vessel.

Biphasic vasodilatation has been observed in therelease process of vasospasm. One is the earlyvasodilatation which occurs immediately after re-moval of barium chloride solution and disappearswithin a few minutes. The other is the late vasodi-latation which appears at the end of the releaseprocess and continues for a longer time, at leastone hour.

Relationship between biphasic vasospasm proposedby Brawley et al. (1968) and biphasic vasodilatationobserved in the present experiment has been dis-cussed, and also a clinical case who suggests post-spastic vasodilatiaton has been demonstrated with theusual and gamma angiographies after the ruptureof the intracranial aneurysm. Ideas of postspasticvasodilatation have been proposed for explanationof the recurrence of intracranial aneurysms.


Copyright © 1972, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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