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AN AUTOPSY CASE OF PRESENILE DEMENTIA WITH MOTOR NEURON DISEASE Yoshio Mitsuyama 1,3 , Isao Takamatsu 2 1Department of Neurology Omuta Rosai Hospital 2Wakahisa Mental Hospital pp.409-416
Published Date 1971/4/1
DOI https://doi.org/10.11477/mf.1406202888
  • Abstract
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Clinical History :

A 60-year-old house wife at the age of 58 years developed an illness consisting of retention defect, preserved language and personality defect. Later muscular atrophy in the arms, thenar and hypothenar was observed. Neurologically deep tendon reflexes of the limbs were normal with no pathological re-flex. Pneumoencephalography revealed a diffuse cerebral atrophy and EMG showed lower motor neuron damage. The illness was aggravated pro-gressively and she died about two years after the onset of the disease.

Gross Anatomical Findings :

1. Atrophies of intra-abdominal organs.

2. Chronic emphysema (senile).

3. Cholelithiasis with chronic cholecystitis.

4. Petechial hemorrhage (stomach, kidney pelvis, and urinary bladder).

Neuropathological Findings :

Brain : weight 1,070 g, diffuse cerebral atrophy which was maked in the frontal lobes.

Microscopic Anatomical Findings :

The cerebral cortex in all areas showed a moderate degree of nerve cell degeneration and some loss of neurons with an astroglial reaction. A mild spon-giose state was present between the second and third layers in the frontal, temporal and central cortices. There was a mild rarefaction of the myelin sheath in the deep white substance of the cerebral hemispheres and in the lateral tract of the spinal cord, but gliosis and fatty granular cells were not observed. In the spinal cord, the loss of anterior horn cells was marked in the cervical cord and mild in the lumbar cord. There were many torpedos in the cerebellum. It is considered that this is an un-classified presenile dementia case assumed to be one of the systemic degenerative diseases of CNS. This group is characterized by an onset of presenility with mental changes, an incomplete type of ALS and by advancement to death within a few years. Pathologically, nonspecific mild degenerative changes are observed throughout the central nervous system.


Copyright © 1971, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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