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A NEW METHOD FOR EEG ACTIVATION WITH BEMEGRIDE Junji YAMAMOTO 1 , Yoshihide YAMADA 1 , Akira FUJIKI 1 , Yasuo HISHIKAWA 1 , Ziro KANEKO 1 1Dept. of Neuropsychiatry, Osaka Univ., Medical School pp.877-887
Published Date 1966/9/1
DOI https://doi.org/10.11477/mf.1406202105
  • Abstract
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Since the introduction by Delay (1956), bemegride has been widely used as an activating substance in the EEG examination of epileptics. Earlier workers adopted methods of injecting at a constant speed re-gardless of the body weight of the subject, although the activating action of the drug is closely related to its injection speed and total dose. In the present work, was adopted a new method of injecting 0.2mg/ kg of bemegride intravenously every 30 sec. up to the maximum dose of 4.0 mg/kg. The injection was stopp-ed when a generalized irregular spike and wave burst or high voltage slow burst was induced in the EEG tracings. The threshold was determined by the amount of the drug injected up to these EEG paro-xysmal changes.

Subjects were 77 epileptics, 24 schizophrenics, 10 psychoneurotics, and 3 normal adults. None of them received medical treatment prior to the present exam-nation.

Results :

(1) Range and mean value of the bemegride thres-hold in the various clinical groups were as follows ; 0.3-4.0 mg/kg, mean 1.3 mg/kg (S. D. 0.8) in epileptics, 0.9-4.0 mg/kg, mean 2.9 mg/kg (S. D. 1.0) in schizophrenics, 2.1-3.1 mg/kg, mean 2.5 mg/kg (S. D. 0.3) in psychoneurotics and 2.4 -2.6 mg/kg, mean 2.5 mg/kg (S. D. 0.1) in normal subjects.

(2) The threshold in "sleep epileptics (Janz)" was considerably higher than the other epileptics ("epi-leptics on awakening " and "diffuse epileptics" according to Janz) ; 2.3-4.0 mg/kg, mean 3.0 mg/kg (S. D. 0.7) in " sleep epileptics " and 0.3 -2.2 mg/kg, mean 1.1 mg/kg (S. D. 0.5) in the other epileptics. From above reason, the data in " sleep epileptics " were excluded from the follow-ing analysis.

(3) In 96% of the epileptics other than sleep epilep-tics, the threshold was 2.0 mg/kg or less. And in 59% of them it was 1.0 mg/kg or less.

(4) No considerable difference between the thresholds of groups of epileptics classified with regards to the characteristics in the resting EEG (normal group, mean, 1.3 mg/kg, S. D., 0.7 ; borderline group, mean, 1.2 mg/kg, S. D., 0.3 ; abnormal group, mean, 1.0 mg/kg, S. D., 0.4).

(5) No significant difference between the mean thres-hold values of focal (0.4-2.2 mg/kg, mean 1.1 mg/kg, S. D. 0.5) and of non-focal (0.3-1.9 mg/kg, mean 0.9 mg/kg, S. D. 0.4) epileptics.

(6) No significant relationship between the threshold and the frequency of attacks.

(7) No statistically significant threshold difference with Age or with Sex.

(8) Seventeen epileptics who were completely seizure-free for 3-11 months by medication of anticon-vulsant were reexamined by bemegride activation. Practically no significant change in the threshold value was found after medication with diphenyl-hydantoin, while trimethadion and phenobarbital raised it considerably (more than 2 times).

(9) In 11 cases (14%) of epileptics, clinical attacks were induced. Ten of them reproduced their own habitual seizure.

(10) A significantly lower threshold in the atypical schizophrenics (mean 2.0 mg/kg) than that in the typical group ; a considerably higher threshold in hebephrenics (mean 3.9 mg/kg).

(11) Psychoneurotics (mainly anxiety neurosis and hy-pochondria) and normal subjects had the same mean threshold value (2.5 mg/kg).

(12) In 7 cases (70%) of psychoneurotics, generalized convulsive attack was induced during examination. In these instances, the initial EEG paroxysmal discharge appeared almost simultaneously with the onset of the clinical attack.


Copyright © 1966, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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