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TREATMENT OF WILSON'S DISEASE, ESPECIALLY ON PENICILLAMINE THERAPY Masataka Arima 1 1Department of Pediatrics Tokyo University Medical School pp.49-55
Published Date 1963/1/1
DOI https://doi.org/10.11477/mf.1406201398
  • Abstract
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From the experiences of penicillamine the-rapy it 10 cases of Wilson's disease, the effect and side effects of penicillamine may be con-cluded as follows:

1) The copper eliminating effect of penici-llamine is greater than BAL and EDTA-Ca.

2) Appearance of the clinical effect of pe-nicillamine appears to be later than BAL. Effects in inhibition of progress of the disease and maintenance of the improved condition, however, last longer than the older agents.

3) As it is given orally, it can be used with-out pain even in children and is convenient for the home treatment.

4) Periodical examination is advisable as it should be administered for a long time al-though no severe side effects, which neces-sitated discontinuation of medication, have been noted so far.

In Wilson's disease, death will take place unless it is treated before the development of irreversible changes. Therefore, early diag-, nosis and treatment are important for the complete control of the disease.


Copyright © 1963, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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