脳波賦活剤としてのアンチバルビの使用経験について

CLINICAL APPLICATION OF ANTIBARBI (MEGINIDE) AS AN ACTIVATOR IN ELECTROENCEPHALOGRAPHY

緒言

　てんかん患者の発作間歇期の安静時脳波記録に於いて，その15〜20％が正常脳波を示す事は良く知られている所である。（Schwab^12），Gibbs^6），　Jasper^11）等）従つて，脳波の臨床的応用に際して，種々の異常波賦活法が極めて重要な意義を有することとなる。然し乍ら，従前より一般に繁用せられている過呼吸賦活法，光刺激賦活法は，その異常波賦活効果を期待し得る適応症例に普遍性を欠く嫌いがある。

　また自然睡眠賦活法は，平常の臨床検査に応用する際，極めて時間的制約が強く，且つ好適なる検査状態を得る事は常に必しも容易ではない。

1) Effects of antibarbi as an activator in EEG were investigated in 12 cases of epil- eptic group and 4 of non-epileptic group with organic cerebral lesions. All cases showed no abnormality in routine recor- dings.

2) The drugs were given intravenously at the rate of 10mg/min. and maximum dose was 200mg.

3) In 83.3% of epileptic group and 75% of non-epileptic group, the abnormalities were activated by antibarbi and their threshold-averages were 1.2mg/kg in epile ptic group and 1.5mg/kg in non-epileptic group respectively.

4) There were no convulsions clinically in all cases by the method of administration above mentioned; in only 2 cases nausea of slight degree was complained as side- effect.

It was concluded that antibarbi reveals the high activating effect and its side-effect is very slight, therefore antibarbi appears to be a useful activator in EEG.