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Systemic Lupus Erythematosus Manifesting as Subarachnoid Hemorrhage Induced by Cortical Venous Thrombosis and Followed by Medial Medullary Infarction Shinya Oshiro 1 , Kazuhisa Motomura 2 , Takeo Fukushima 3 1Department of Neurosurgery, Okinawa Prefectural Miyako Hospital 2Department of Internal Medicine, Okinawa Prefectural Miyako Hospital 3Depatment of Neurosurgery, School of Medicine, Fuku-oka University Keyword: antiphospholipid syndrome , medial medullary infarction , systemic lupus erythematosus , subarachnoid hemorrhage , venous thrombosis pp.791-795
Published Date 2003/9/1
DOI https://doi.org/10.11477/mf.1406100563
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Abstract

A 43-year-old female, who had been treated for systemic lupus erythematosus(SLE), presented with a subarachnoid hemorrhage(SAH)induced by rupture of cortical venous thrombosis, and be followed by medial medullary infarction during the acute stage of the SAH. The patient initially manifested a SAH. Angiography demonstrated no evidence of any aneurysms or arteriovenous malformations, but revealed cortical venous thrombosis. She suddenly developed left hemiplegia caused by medial medullary infarction on the 6th day. An active anticoagulant therapy was thought to be inappropriate because of initial symptoms as a hemorrhage. Since she had been accompanied by the medullary infarction, then, initially started by antiplatelet therapy. After the confirmation of no saccular or dissecting aneurysms with 2nd angiography, her treatment could be changed to anticoagulant therapy. Because of the sustained negative reactions of anti-cardiolipin b2 glycoprotein I antibody and lupus anticoagulant during the course of SLE, the definite diagnosis of antiphospholipid syndrome(APS)could not be made. However, this case is pathogenically thought to be cerebrovascular disease based upon APS, considering that this syndrome may be related to various antigen/antibody systems.


Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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