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要旨 患者は46歳女性。15歳時から全身性エリテマトーデス(SLE)に対して,prednisoloneの内服で加療されている。また,抗リン脂質抗体症候群(APS)によると考えられる2回の流産歴がある。30歳時に中枢神経ループス(NPSLE)による痙攣発作があり,その後から構音障害と四肢の舞踏運動が出現。頭部CTで両側基底核・前頭葉皮質下白質・小脳歯状核に対称性に広汎な石灰化を認めた。代謝性疾患を含めた他の原因は否定され,長い経過の中でNPSLEとAPSの両者が頭蓋内石灰化の形成に関与した可能性が考えられた。
We report a 46-year-old woman who extensively showed intracranial calcifications possibly due to neuropsychiatric systemic lupus erythematosus (NPSLE) and antiphospholipid syndrome (APS). She had been treated with oral prednisolone for SLE since age 15, and experienced two abortions due to APS at ages 28 and 35 respectively. After a convulsion attack due to NPSLE at age 30, she had been suffering from dysarthria and choreic movement in her extremities. On admission to our hospital brain CT demonstrated extensive and symmetrical calcifications bilaterally in basal ganglia, subcortical white matter of the frontal lobe and dentate nuclei. She was shown to have neither metabolic nor congenital disorders causing these intracranial abnormalities. In this patient both NPSLE and APS, therefore, might have contributed to the remarkable intracranial calcifications in a long clinical course.
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