下痢症状なく，発熱，腹痛のみを前駆症状とし，Campylobacter jejuni(Penner A群)陽性であったGuillain-Barré症候群の1例

Guillain-Barré Syndrome Associated Campylobacter jejuni Serogroup Penner A Showing Antecedent Fever and Abdominal Pain without Diarrhea

要旨　症例は28歳の女性。発熱，腹痛の8日後に手足のしびれと脱力を自覚した。神経伝導速度検査では全体に低振幅で軸索障害を疑わせる所見があり，Guillain-Barré症候群（GBS）と診断した。下痢症状は認めなかったが，便培養にてCampylobacter jejuni（C. jejuni）が分離された。GBSで多く分離されるPenner 19型ではなく，比較的稀とされるPenner A群が検出され，IgG抗GM1抗体も陽性であった。免疫グロブリン大量療法への反応は良好であった。Penner A群のGBS例の詳細な症例報告はなく，貴重な症例と考えた。

We reported a 28-year-old woman who had Guillain-Barré syndrome （GBS）. Eight days after fever up and abdominal pain, she had weakness and dysesthesia of both hands and feet. Campylobacter jejuni （C. jejuni） was isolated from her stool culture without diarrhea. IgG anti-GM1 antibody was detected in her serum. Nerve conduction studies revealed a predominantly axonal neuropathy. After intravenous immunoglobulin therapy, her symptoms promptly improved. Penner 19 of C. jejuni was isolated more frequently from the GBS patients than from sporadic enteritis patients. In this case, C. jejuni with the serogroup Penner A was isolated. The serogroup is detected rarely in GBS.

（Received : January 25, 2005）