スマトリプタン点鼻液が有効であった群発頭痛の3例

Sumatriptan Nasal Spray for the Treatment of Cluster Headache

要旨　群発頭痛3例においてスマトリプタン点鼻液を用いた経験を報告する。スマトリプタン点鼻液は，全ての症例で頭痛発作を頓座させる有効性を示したが，有効性においても速効性においても，スマトリプタン注と比較すると劣っていた。スマトリプタン点鼻液は効果の持続性において酸素吸入よりも優れていた。スマトリプタン点鼻液は，群発期初期の症例にも，後期の症例にも有効であった。

　スマトリプタン点鼻液は，群発頭痛患者の入院期間を短縮させたり，比較的軽症の群発頭痛患者では外来診療を可能にするかもしれない。

We report three cases with cluster headache treated with sumatriptan nasal spray. In all occasion, sumatriptan nasal spray showed meaningful relief in patients with cluster headache, although the efficacy were less than that of sumatriptan subcutaneous injection. Sumatriptan nasal spray needed 20 to 30 minutes to meaningful relief, while subcutaneous injection needed only 5 to 10 minutes. Recurrence of attack was more frequent in oxygen inhalation therapy than sumatriptan nasal spray. Sumatriptan nasal spray were constantly effective in both early stage and late stage of cluster periods.

　Sumatriptan nasal spray may shorten the admission period of severe case of cluster headache. Sumatriptan nasal spray may enable doctors to treat mild cases of cluster headache in their outpatient clinic.

（Received : December 21, 2004）