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Serum Prolactin Levels Following Limbic Seizures in a Case of Epileptic Psychosis:limbic permeability as a possible explanation for pathophysiogenesis Sumio HARA 1 , Naohiro YOKOYAMA 2 , Shigeki TAKEI 1 , Tsunekatsu HARA 3 1Department of Neuropsychiatry, School of Medicine, Keio University 2Otsuka Metropolitan Hospital 3Komagino Hospital Keyword: Prolactin , Limbic seizure , Epileptic psychosis , Limbic permeability pp.829-834
Published Date 1996/8/15
DOI https://doi.org/10.11477/mf.1405904151
  • Abstract
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 Postictal serum prolactin (PRL) elevation results from the spread of ictal discharge involving limbic structures to the hypothalamus. To indirectly explore the nature of the ictal discharge in a male psychotic temporal lobe epileptic aged 39 (seizure and psychosis onset at the ages of 6 and 25, respectively), serial PRL levels following limbic seizures (2 complex partial and3 psychic) were studied.

 The baseline samples were drawn a week after each event when the patient was seizure-free for at least 12 hours. The peak levels (15 minutes after the onset of events) following complex partial seizures revealed 94 and 95ng/ml, and those of psychic seizures, 84, 43 and 28ng/ml. These peak levels are about 9 times as high as the basal level (10.0±4.0ng/ml) in complex partial seizures and 3 to 8 times in psychic seizures. The degree of elevations in this case far exceeds those recorded in previous reports. If it is true that the higher the peak level, the more intensified and inclined to spread is the ictal discharge, limbic permeability may develop in this patient. As shown in this case, ictal fear sometimes heralds illusion of reference, a feeling of somebody being nearby and Ma vu, all of which are ascribed to sensory-limbic hyperconnection (Bear, D).

 In conclusion, limbic permeability in combination with sensory-limbic hyperconnection is partly the pathophysiogenesis of epileptic psychosis.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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