Spike Wave Stupor Related to Menstrual Cycles Naohiro YOKOYAMA 1 , Takao UEHARA 1 , Sumio HARA 2 , Tsunekatsu HARA 3 1Tokyo Metropolitan Ohtsuka Hospital 2Department of Neuropsychiatry, School of Medicine, Keio Gijuku University 3Komagino Hospital Keyword: Spike wave stupor , Petit mal status , Absence status , Menstrual cycles , Endocrinological therapy pp.951-957
Published Date 1993/9/15
DOI https://doi.org/10.11477/mf.1405903514
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 We reported two cases of spike wave stupor (SWS) which were related with menstruation cycles. The first case; a woman of 39, since undergoing artificial abortion at the age of 27 has shown a twilight state persisting for 1 or 2 days and generalized convulsion before menstruation every month. She had not received antiepileptic drugs (AED) as medication. During the twilight episode, electroencephalography showed continuing diffuse slow polyspike and wave complexes. Pseudomenopausal therapy using danazol failed to control SWS. Valproic acid (VPA) was effective for shortening of SWS duration, but SWS is still persisting. The second case, a woman of 37, had had a brief psychotic episode when she was 20. At that time she had her first convulsive seizure. The seizures were not controlled completely by AED. When she was 28, she showed a twilight state after convulsive seizures and it was correlated with her menstrual cycles. Such episodes appeared chiefly before and after menstruation. At the beginning of the SWS state, electroencephalography showed right temporal spikes, but in the state of deep stupor diffuse spike and wave bursts were observed. VPA was effective, but SWS is still continuing at the perimenstrual period. By reviewing a total of six cases of SWS that are correlated with menstruation in Japan, we discussed its clinical features.

Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.


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