Seishin Igaku Volume 52, Issue 2 (February 2010)

Successful Use of Olanzapine in the Treatment of Severe Impulsive Behavior in Huntington' s Disease Masa IEDA 1 , Tsuyoshi MIYAOKA 1 , Akira NISHIDA 1 , Takuji INAGAKI 1 , Jun HORIGUCHI 1 , Naoto KOHNO 2 , Ryo MIZUHARA 2 1Department of Psychiatry, Faculty of Medicine, Shimane University, Izumo, Japan 2Shimane Prefectural Central Hospital Keyword: Huntington's disease , Olanzapine , Increased impulsive state , Hallucinatory paranoid state pp.173-176
Published Date 2010/2/15
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 Huntington's disease (HD), which results from a mutation in chromosome 4, is marked by a decrease in the neurotransmitter (GABA, substance P, etc) level in the basal ganglia. Clinically, it is characterized by a triad of motor, cognitive, and psychiatric disturbances. Antipsychotic drugs, especially dopamine antagonists, have been shown to be effective in the control of these symptoms;however, their use is limited by the occurence of adverse effects that are characterized mainly by extrapyramidal symptoms.

 Here, we report the case of a 42-year-old woman with HD who presented with severe impulsive behavior, hallucinations, and delusions, in addition to severe chorea. After admission, we administered haloperidol (3mg/day);this led to an improvement in the psychomotor excitation. Three weeks after admission, she presented again with aggravated impulsive, hallucinations, and delusions. Her symptoms were alleviated by olanzapine (20mg/day) therapy. Eight weeks after admission, she was discharged from the hospital, and the symptoms have not recurred during the 1-year follow-up period. Therefore, we concluded that olanzapine appears to be useful in the teratment of psychiatric symptoms of HD.

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52巻2号 (2010年2月)
電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院