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Japanese

Studies on Long-term Treatment of Eldery Hypertension with Special Reference to Monotherapy Using Ca Channel Antagonist, Nilvadipine Nobutaka Doba 1 , Masaki Shukuya 2 , Hideo Yoshida 1 , Yasusi Nakamura 3 , Yuugen Inoue 4 , Takeo Uchida 4 1Department of Internal Medicine III, Teikyo University School of Medicine, Ichihara Hospital 2Social Insurance Joto Hospital 3Youkaichiba Municipal General Hospital 4Ichihara Medical Association Keyword: Ca拮抗薬 , 高年者高血圧 , 長期単剤治療 , Ca-antagonist , eldery hypertensives , long-term monotherapy pp.193-198
Published Date 1996/2/15
DOI https://doi.org/10.11477/mf.1404901202
  • Abstract
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OBJECTIVES: Efficacy of long-term antihyperten-sive treatment on elderly hypertensive patients with nilvadipine was assessed with regard to blood pressure lowering and cardiovascular events. METHODS: One hundred and twenty seven elderly hypertensives visitedto 20 multiple hospitals, clinics and dispensaries in Ichihara and Yohkaichiba areas, Chiba prefecture from April 1989 to March 1990. Nilvadipine (2mg) was prescribed one to two tablets twice a day for 3 years. Evaluation was performed on blood pressure. routine laboratory data and cardiovascular events. RESULTS: Twenty one cases dropped-out because of drug adverse effects, movements, poor patient compliance and other unidentified reasons. As a whole in 104 cases, depres-sant effect was obtained within initial 3 months and it was maintained thereafter for 3 years. Age and gender did not affect the therapeutic efficacy, but higher the initial blood pressure level, the greater the depressanteffect. There were no cardiovascular deaths observed. Nonfatal cardiovascular events, however, were not significantly related to age and the initial blood pres-sure levels, but gender and severity grade after WHO criteria. CONCLUSIONS : Long-term treatment with nilvadipine on elderly hypertensives was effective to maintain the blood pressure level within the adequate therapeutic range for 3 years. Male and increased severity grade after WHO criteria were identified as significant risk predictors with regard to nonfatal car-diovascular events.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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