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A Case of Chronic Necrotizing Pulmonary Aspergillosis Followed up for 12 Years Hirokazu Kato 1 , Osamu Kanazawa 1 , Yoshihiro Hayashi 1 , Teturi Kondo 1 , Sumie Shioya 1 , Yasuyo Ohta 1 1Department of Internal Medicine, Tokai University School of Medicine Keyword: 肺の空洞性病変 , アスペルギルス感染 , 肺生検 , cavitary pulmonary lesion , aspergillus infection , lung biopsy pp.605-608
Published Date 1995/6/15
DOI https://doi.org/10.11477/mf.1404901074
  • Abstract
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We report a case of a 76-year-old nonimmunocom-promised male who was diagnosed as having chronic necrotizing pulmonary aspergillosis (CNPA) from findings of a transbronchial lung biopsy (TBLB) and the time course of chest X-ray. He had received follow-up chest X-ray for 12 years since fibrotic changes were found in his bilateral lung base. Five years before the diagnosis of CPNA, new infiltrative changes appeared in the right upper lobe, then the infiltrates developed to a cavitary mass lesion with a fungus ball suggesting primary aspergilloma. Aspergil-lus species were cultured from his sputum and the TBLB specimens showed invasive aspergillus infiltration and necrotic changes of lung tissue. At the same time, he had episodes of asthmatic attacks with stridor. He had a high IgE RAST score, precipitating antibody and positive skin test reaction to aspergillus, and positive airway hypersensitivity test reaction to methacholine. The case suggested that a complication of allergic bronchopulmonary aspergillosis could occur in a similar patient with CNPA.


Copyright © 1995, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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