Japanese

Linkage Analysis in a Japanese Long QT Syndrome Family Kaoru Akimoto 1,3 , Rumiko Matsuoka 1 , Hiroshi Kasanuki 2 , Atsuyoshi Takao 1 , Kazuo Monma 1 , Kunio Hayakawa 3 , Saichi Hosoda 2 1Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College 2Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College 3Department of Pediatrics, Miyazaki Medical College Keyword: QT延長症候群 , Romano-Ward症候群 , 連鎖解析 , long QT syndrome , Romano-Ward syndrome , linkage work pp.463-465
Published Date 1993/5/15
DOI https://doi.org/10.11477/mf.1404900667
  • Abstract
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Romano-Ward syndrome is an autosomal dominant trait disease, which is characterized by QT prolonga-tion and normal hearings and shows predisposal to sudden death from cardiac arrhythmia. Recently, Keat-ing et al. reported that Harvey ras-1 locus (H-ras-1) was closely linked to long QT syndrome (LQTS), being located on the short arm of chromosome 11. In this study we have examined a three-generation Japanese family whose members had recurrent fainting with prolongation of the QT interval on electrocardgram. Using the H-ras-1 probe as DNA marker, we could not determine that the H-ras-1 gene was linked to LQTS.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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