Effects of Isosorbide Dinitrate on Coronary and Systemic Circulation in Children Kenji Hamaoka 1 , Koichi Sakata 1 , Yutaka Omochi 1 , Yasutaka Kamiya 1 , Zenshiro Onouchi 1 1Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine Keyword: 硝酸イソソルビド(isosorbide dinitrate) , 冠循環動態(coronary circulation) , 小児(children) pp.595-600
Published Date 1991/6/15
DOI https://doi.org/10.11477/mf.1404900297
  • Abstract
  • Look Inside

The effects of isosorbide dinitrate (ISDN) on the coronary and systemic circulation were evaluated in 8 children with angiographically normal coronary arteries. ISDN, 100μg/kg, was given as a intracoronary injection.

The pulmonary artery pressure, pulmonary capillary wedge pressure and left ventricular end-diastolic pres-sure which are related to the pre-load were significantly reduced 1 min after the ISDN injection. The systolic blood pressure was reduced, and heart rate increased. The cardiac output, pressure-rate product and systemic vascular resistance showed no significant change.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院