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Electrophysiologic effects of intravenous digoxin in infants and children with Wolff-Parkinson-White syndrome Yoshiki Fujiseki 1 , Fujino Hidetoshi 1 , Noriyasu Umemura 1 , Setsuko Nishijima 1 , Masanori Hattori 1 , Morimi Shimada 1 , Toshiaki Sugiyama 2 , Ryouichi Nishikawa 2 , Nobuyuki Kiyosawa 3 , Ryuuzou Mizuta 3 1Department of Pediatrics Shiga University of Medical Science 2Department of Pediatrics, Ohmihachiman City Hospital 3Department of Pediatrics, Kyoto 2nd Red Cross Hospital pp.891-894
Published Date 1989/8/15
DOI https://doi.org/10.11477/mf.1404205528
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Electrophysiologic properties of the accessory pa-thway were investigated before and after the intra-venous administration of digoxin (0.01~0.02mg/kg) during electrophysiologic studies in 14 infants and children with the Wolff-Parkinson-White syndrome.

Determination of electrophysiologic properties of the accessory pathway was made using transesopha-geal atrial pacing and/or intracardiac right atrial pacing.

Maximal effect on the accessory pathway after in-travenous digoxin was observed during one to six hours. Effective refractory period of the accessory pathway increased in 6 of the 14 patients, de-creased in 4 and unchanged in 4. Shortest AP 1 : 1 conduction increased in 5 of the 12 patients, decrea-sed in 3 and unchanged in 4.

Tachycardia was not induced after digoxin in only one patient. Tachycardia cycle length, ventriculo-atrial conduction time and atrioventricular conduc-tion time were unchanged after digoxin in almost all cases.

Thus, digoxin is not the first choice drug for ter-mination and prevention of the preexcitation syndro-me.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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