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Exercise testing in patients with hepatic failure Sadako Hiraishi 1 , Miyoko Hirokawa 2 , Kunio Suwa 1 , Isamu Nishi 3 1Department of Anesthesia, Faculty of Medicine, University of Tokyo 2Cyuō Tetsudou Hospital 3Department of Mass-spectrometry, Tokyo Science University pp.171-176
Published Date 1987/2/15
DOI https://doi.org/10.11477/mf.1404205007
  • Abstract
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 Exercise testings using an ergometer were performed on 21 preoperative patients. They were composed of two groups, patients with hepatic failure (hepatic failure group, n=9) and those without hepatic failures (control group, n=12).

 The testing started with the load of 25 W/h, and the load was increased by 12. 5W/h every minute, until the heart rate of the patient reached the 80% of the expected maximum.

 Oxygen consumption rate (VO2), expired gas volumes/ minutes (VE) and the heart rate (HR) were measured and the anaerobic threshold was determined. Results indicate,

 1) The ratio of VO2 to VE of the hepatic failure group was only 85% of that of the group, and this was mainly due to the high VE at the restig state in the hepatic failure group.

 2) In the hepatic failure group, the ratio of VO2 to VE reached a maximum point with a relatively low load, meaning that anaerobic thresholds of the hepatic failure group were much lower than those of the contol group.

 3) The ratio of VOz to HR for each additional load and the maximum exercise level tolerable in the hepatic failure group, were considerably lower than those in the control group.

 From these findings, we conclude that, in patients with hepatic failures, the anaerobic metabolism takes place at a very low level of exercise load. Furthermore, the aerobic metabolism appears inhibited either due to hepatic dysfunction or due to hypoxemia, seen often in patients with severe hepatic failure, such as liver cirrhosis.


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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