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Experimental evaluation of calcium channel blockers for preventing coronary atherosclerosis in the heterotopic rat allograft Kenji Kasahara 1 , Hong-xu Zhao 2 , Salim Aziz 2 , Stuart Jamieson 2 , Norman Shumway 2 , Terumasa Kagawa 1 1Department of Thoracic and Cardiovascular Surgery, Kansai Medical School pp.177-181
Published Date 1986/2/15
DOI https://doi.org/10.11477/mf.1404204822
  • Abstract
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This experiment is designed to evaluate the effect of calcium channel blockers (Nifedipine and Vera-pamil) in the process of atherosclerosis in cardiac allograft for the experimental heterotopic heart trans-plantation by using rats. In this study, a level of serum cholesterol in the groups with Nifedipine is higher than compared with the groups without Ni-fedipine. The myocardial calcium content in thetransplanted hearts is significantly higher in all groups compared with those in recipients heart. And the myocardial calcium content in a group treated with CsA (Cyclosporin A) +Nifedipine, is significantly lower in transplanted heart than those in a group treated with CsA alone.

Calcium channel blockers reduced the calcium con-tent in the host heart aortic tissue, partly in the cardiac allograft. But the microscopical evaluation of transplanted heart coronary artery shows vessel disease in all group with varying degree of athero-sclerosis, and there is no significant difference a-mong these groups.

We conclude that calcium channel blockers did not prevent cardiac allograft coronary artery athe-rosclerosis.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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