老人の血液脳関門に関する研究—（附）ウラニンの副作用

Studies on Blood-Brain Barrier in the aged.:Ill effect of uranin.

I．緒言

　血液脳関門（Blood-Brain Barrier, B-B—B）の本態に関しては，未だ充分に解明せられていないが，老人の脳循環に関する数多のN₂O法，或いは病理学的成績からみて，老人のB-B—Bは青年のそれと異なることが推測される。

　著者は先に脳における酸素需要供給平衡の総合因子たる脳酸素摂取率（CERO₂）が，脳循環動態，特に脳動脈硬化の機械的一指標として臨床的に有意義であることを報告した^1）が，今回は更にこのCERO₂とB-B—Bとの相関を検索し，脳動脈硬化判定に関するB-B—Bの臨床上補助的意義を検討した。

Studies on the blood-brain barrier (B-B-B) in the normal old age. The relationship between blood-brain barrier (B-B-B) and cerebral oxygen intake (CERO₂), blood pressure, cerebrospinalfuid pressure was investigated in the normal old age by uranin method. No correlation was found between B-B-B and CERO₂, blood pressure but significant correlation was found between B-B-B and cerebrospinal fluid pressure. From this results B-B-B does not appear to be a measure of the intensity of cerebral arteriosclerosis. Abnormal valure of B-B-B was found in about 1/3 of the normal old age in this studies. One person suffered from shock accidentally in this studies, and various ill effect of uranin was mentioned.