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Non-Helicobacter pylori Helicobacter-associated Gastric Mucosa-associated Lymphoid Tissue Lymphoma Hidehiko Takigawa 1 , Ryo Yuge 1 , Daisuke Shimizu 2 , Ryo Miyamoto 2 , Rina Otani 2 , Hiroki Kadota 2 , Yasuhiko Kitadai 3 , Shiro Oka 2 , Shinji Tanaka 1 1Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan 2Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan 3Department of Health and Science, Prefectural University of Hiroshima, Hiroshima, Japan Keyword: NHPH , non-Helicobacter pylori Helicobacter , 胃MALTリンパ腫 , H. pylori陰性胃MALTリンパ腫 , 鳥肌胃炎様胃MALTリンパ腫 , 除菌治療 pp.61-70
Published Date 2023/1/25
DOI https://doi.org/10.11477/mf.1403203092
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 Fusion of the API2-MALT1 gene and H. pylori(Helicobacter pylori)infection is a well-established etiology of gastric MALT(mucosa- associated lymphoid tissue)lymphoma ; however, the existence of NHPH(Non-Helicobacter pylori helicobacter)-induced gastric MALT lymphoma has been recently reported. In this study, the role of NHPH infection in gastric MALT lymphoma and its response to eradication therapy and endoscopic characteristics are summarized. Our previous study reported that NHPH infection occurred in 16(55%)of the 29 patients with API2-MALT1 and H. pylori, both negative for gastric MALT lymphomas, and was therefore considered as the major cause of H. pylori-negative gastric MALT lymphomas. However, patients with H. pylori-negative gastric MALT lymphoma exhibited a low remission rate via eradication therapy, while those with NHPH-positive lymphomas had a high remission rate(12/16, 75%). The endoscopic images of NHPH-positive gastric MALT lymphoma are characterized by microgranular changes, such as nodular gastritis-like appearance and MLP(multiple lymphomatous polyposis)-like changes. The background mucosa of patients with NHPH infection also displays unique characteristics. Therefore, gastric MALT lymphoma should be treated while considering the possibility of an NHPH infection and the endoscopic characteristics caused by it.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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