Gastritis Associated with Helicobacter heilmannii-like Organism Yoko Okiyama 1 , Kenji Matsuzawa 1 , Tsutomu Katsuyama 1 , Masataka Higuchi 1 , Tsuneo Nakajima 1 , Kazutoshi Maruyama 1 , Takehisa Matsumoto 2 , Hiroyoshi Ota 3 , Yugo Iwaya 4 , Taiji Akamatsu 5 1Department of Internal Medicine, Maruko Central Hospital, Ueda, Japan 2Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan 3Departments of Clinical Laboratory Sciences, Shinshu University School of Health Sciences, Matsumoto, Japan 4Secound Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan 5Endoscopy Center, Nagano Prefectural Suzaka Hospital, Nagano Prefectural Hospital Organization, Suzaka, Japan Keyword: HHLO(Helicobacter heilmannii-like organism) , NHPH , 胃MALTリンパ腫 pp.105-115
Published Date 2016/1/25
DOI https://doi.org/10.11477/mf.1403200530
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 Helicobacter spp. hat exhibit a large helical form, collectively referred to as HHLO(Helicobacter heilmannii-like organism), are a cause of zoonotic infections, and a mild gastric mucosal disorder is often observed. However, in recent years, this organism has attracted attention because of its suggested association with nodular gastritis and gastric MALT(mucosa-associated lymphoid tissue)lymphoma. The infection rate of our cases in Japan is 0.1%, which is approximately the same as in other developed countries. Eradication therapy was performed in six patients with HHLO-associated gastric MALT lymphoma, including one who underwent additional radiation therapy, and all six cases have maintained remission.

 The probability of encountering a case of HHLO infection in everyday clinical practice is low compared with that of Helicobacter pylori infections. However, it may be noteworthy with respect to the development of MALT lymphoma.Thus, the establishment of culture methods as well as analysis and classification using molecular biology techniques are expected.

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