Recent Progress in the Histopathological Classification of Gastric Signet-ring Carcinoma Tomio Arai 1 1Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo Keyword: 胃癌 , 印環細胞癌 , poorly cohesive carcinoma , WHO分類 pp.1356-1366
Published Date 2021/9/25
DOI https://doi.org/10.11477/mf.1403202562
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 Although the incidence of gastric cancer is decreasing worldwide, that of signet-ring cell carcinoma is increasing in the western countries. Therefore, more attention needs to be paid to tumors. Signet-ring cell carcinoma has been classified as one of the common histological subtypes in the Japanese classification. Whereas, signet-ring cell carcinoma has been classified as poorly cohesive carcinoma according to the 4th edition of the World Health Organization classification ; however, it was revised as an independent histological type in the 5th edition. To improve the ambiguity of the definition of signet-ring cell carcinoma and the lack of standardization of its pathological diagnosis, a European research group proposed a novel definition based on the proportion of signet-ring cells in tumor. Although no international consensus has been reached yet, it may affect medical care and research of signet-ring cell carcinoma in the future. In addition, the relationship between the presence or absence of a layered structure and the expression of intestinal phenotype in signet-ring cell carcinoma, biological behaviors, and hereditary gastric cancer have recently attracted attention.

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