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Tumor Budding/Sprouting in Submucosal Invasive Colorectal Cancer. Its Clinicopathological Significance and Diagnostic Problems Hiroshi Kawachi 1 , Yoshinobu Eishi 1 , Morio Koike 2 1Department of Human Pathology, Tokyo Medical and Dental University, Tokyo 2Department of Health and Medical Technology, Bunkyo Gakuin University, Tokyo Keyword: 大腸SM癌 , 簇出 , リンパ節転移 , サイトケラチン , 免疫染色 pp.1249-1254
Published Date 2009/7/25
DOI https://doi.org/10.11477/mf.1403101720
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 “Tumor budding/sprouting”is a strong predictive factor for lymph node metastasis of submucosal invasive colorectal cancer. In the study for interobserver reproductivity, tumor budding/sprouting revealed a higher kappa value than lymphatic permeation. In some cases, it is difficult to differentiate cancer cells from fibroblast or endothelial cells in desmoplastic reaction, and macrophages in inflammation.

 Immunohistochemistry using anti-cytokeratin antibody is very useful for identifying such difficult cancer cells. To make tumor budding/sprouting a more significant factor, however, we should clarify the usefulness of immunostaining and adequate cutoff point by analysis of a large number of cases in the future.


Copyright © 2009, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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