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Clinical Significance of Tumor Budding and Poorly Differentiated Clusters in T1 Colorectal Cancers Hideki Ueno 1 , Eiji Shinto 1 , Hideyuki Shimazaki 2 , Junji Yamamoto 1 , Kazuo Hase 1 1Department of Surgery, National Defense Medical College, Tokorozawa, Japan 2Department of Pathology, National Defense Medical College, Tokorozawa, Japan Keyword: 大腸T1(SM)癌 , 簇出 , 低分化胞巣 , リンパ節転移 pp.1057-1062
Published Date 2014/6/25
DOI https://doi.org/10.11477/mf.1403114207
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 Novel risk factors for lymph node metastasis in pT1 CRC(colorectal cancer)have been recently proposed, but most have not been implemented because they have not been validated. Therefore, we evaluated the value of tumor budding, depth of submucosal invasion, and presence of PDC(poorly differentiated clusters)in a multi-institutional cohort of T1 CRC cases recruited from 30 institutions at the 75th meeting of the Japanese Society for Cancer of the Colon and Rectum. We found all three factors to be statistically significant(all, p<0.0001). The predictive power of risk stratification was found to be most favorable for vascular invasion, followed by PDC ; submucosal invasion depth was the most unfavorable. PDC may thus be a promising new parameter to determine whether an observational policy can be safely applied following local tumor excision in pT1 CRC cases. However, large-scale multicenter prospective studies are required to validate the use of PDCs in clinical management and to determine whether it should be included in the diagnostic routine.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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