Photodynamic Therapy for T1b Esophageal Cancer Hiroki Yamashita 1 , Tatsunori Minamide 1 , Tomonori Yano 1 1Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan Keyword: 食道癌 , 光線力学療法 , PDT , 化学放射線療法後局所遺残再発 , サルベージ治療 , レザフィリン® pp.1283-1293
Published Date 2020/9/25
DOI https://doi.org/10.11477/mf.1403202141
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 PDT(photodynamic therapy)is an endoscopic salvage treatment used for local failure after CRT(chemoradiotherapy)for esophageal cancer. Salvage esophagectomy is generally indicated for patients with local failure after CRT ; however, it is associated with a high rate of postoperative complications and mortality. PDT is a minimally invasive salvage treatment that can be radically effective even for patients considered inoperable due to physical intolerance or refusal to consent to surgery. PDT with talaporfin sodium, approved for use in 2015, is much more convenient and produces more favorable short-term outcomes, including local control and safety, compared to PDT with porfimer sodium. Earlier detection of local failure with post-CRT endoscopy at appropriate intervals enables patients to receive minimally invasive salvage endoscopic treatment. Some reports have identified factors that predict the therapeutic efficacy of endoscopic salvage treatment and can be used to inform the selection of an endoscopic treatment strategy against local failure after CRT.

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