H. pylori未感染胃上皮性腫瘍の臨床的特徴

Clinical Characteristics of Helicobacter pylori Naïve Gastric Neoplasia

要旨●H. pyloriの感染率は低下しているため，H. pylori感染胃癌と比べてH. pylori未感染胃癌は相対的に増加すると予想される．今回，2010年1月〜2016年5月の期間に当院（大阪国際がんセンター）で経験した，H. pylori未感染胃癌の臨床的特徴を考察した．H. pylori未感染胃癌の頻度は早期胃癌全体の1.26%と低く，若年例，U領域，未分化型癌が多かった．また，分化型癌の粘液形質は胃型の割合が高かった．

　Because the H. pylori（Helicobacter pylori）infection rate is decreasing, it is expected that the relative number of H. pylori-naïve gastric cancer cases will increase. In this study, we examined clinical characteristics of H. pylori-naïve gastric cancer cases experienced in our institution between January 2010 and May 2016. The H. pylori-naïve gastric cancer proportion was low, at 1.26%. Our findings indicate that H. pylori-naïve gastric cancers were more frequent in young patients, were generally in upper-third locations, and of undifferentiated histological type. In addition, among all differentiated lesions, the proportion showing a gastric mucin phenotype was larger in H. pylori-naïve gastric cancers than in H. pylori-associated gastric cancers.