Stomach and Intestine(Tokyo) Volume 54, Issue 7 (June 2019)

Pathological Findings of Autoimmune Gastritis Yasuharu Kaizaki 1 , Hiroyuki Aoyagi 2 , Akiya Kogami 1 , Toshie Hara 1 , Yoshiaki Hayashi 3 1Department of Pathology, Fukui Prefectural Hospital, Fukui, Japan 2Department of Gastroenterology, Fukui Prefectural Hospital, Fukui, Japan 3Department of Gastroenterology, Komatsu Municipal Hospital, Komatsu, Japan Keyword: A型胃炎 , 自己免疫性胃炎 , 病理組織学的所見 pp.963-971
Published Date 2019/6/25
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 To clarify the pathological findings of autoimmune gastritis, we examined 9 surgical and 28 endoscopic cases of biopsy and resection. Initially, lymphocytic and eosinophilic infiltration predominates in the deep mucosa of the fundic gland region, causing the destruction and disappearance of parietal cells. The chief cells are kept relatively, and the fundic glands exhibit pseudopyloric gland metaplasia. When the fundic glands disappear, they are replaced by true pyloric gland metaplasia, intestinal metaplasia, and pancreatic acinar metaplasia. Endocrine cell hyperplasia is also observed. Additionally, the foveolar epithelium demonstrates mild atrophy, cystic changes, and hyperplasia until the terminal stage. In the pyloric gland region, no mucosal atrophy is observed, but findings of bile reflux gastropathy and fibromusculosis within the mucosa is often noted.

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54巻7号 (2019年6月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院