Stomach and Intestine(Tokyo) Volume 52, Issue 4 (April 2017)

The Pathological Characteristics of Endocrine Cell Tumor of the Gastrointestinal Tract Yasuharu Kaizaki 1 , Akiya Kogami 1 , Toshie Hara 1 , Hiroyuki Aoyagi 2 , Tamon Miyanaga 3 , Kenji Dohden 3 , Masakazu Hattori 3 1Department of Pathology, Fukui Prefectural Hospital, Fukui, Japan 2Department of Gastroenterology, Fukui Prefectural Hospital, Fukui, Japan 3Department of Surgery, Fukui Prefectural Hospital, Fukui, Japan Keyword: 内分泌細胞腫瘍 , 消化管 , カルチノイド(NET) , 内分泌細胞癌(NEC) pp.390-401
Published Date 2017/4/25
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 Endocrine cell tumor is classified as carcinoid tumor with slow growth, and ECC(endocrine cell carcinoma)is characterized with rapid growth and poor prognosis. The mechanism of development of both these tumors is different. The histological findings of endocrine cell tumors show a monotonous structure consisting of alveolar or solid growth with relatively homogeneous cells. The presence of atypia or necrosis of cells makes it relatively easy to make a diagnosis and also gives information about tissue origin. In the WHO classification, neuroendocrine neoplasms of the pancreas and gastrointestinal tract are together classified as NET(neuroendocrine tumor)G1, NET G2, and NEC(neuroendocrine carcinoma)with cell proliferation ability, without the consideration of tissue origin. The problem that persists since the announcement of the classification is that the tumors of different origin and characteristics such as carcinoids with high cell proliferation ability and endocrine cell carcinoma are grouped under the same classification. Recently, a classification that includes tumor origin is under consideration.

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52巻4号 (2017年4月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院