Stomach and Intestine(Tokyo) Volume 54, Issue 7 (June 2019)

Clinical Characteristics and Serological Findings of Type A Gastritis Tomoari Kamada 1 , Naoki Sumi 1 , Mitsuhiko Suehiro 2 , Noriaki Manabe 3 , Hirofumi Kawamoto 2 , Akiko Shiotani 4 , Yasumasa Monobe 5 , Kazuhiko Inoue 6 , Nobumi Hisamoto 6 , Toshihiro Takao 1 , Ken Haruma 2 1Department of Health Care Medicine, Kawasaki Medical School, Kurashiki, Japan 2Department of General Internal Medicine 2, Kawasaki Medical School, Kurashiki, Japan 3Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan 4Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan 5Department of Pathology, Kawasaki Medical School, Kurashiki, Japan 6Long Life Hospital, Junpukai, Okayama, Japan Keyword: A型胃炎 , 自己免疫性胃炎 , 抗胃壁細胞抗体 , 悪性貧血 , H. pylori感染 pp.973-981
Published Date 2019/6/25
  • Abstract
  • Look Inside
  • Reference

 Type A gastritis is currently considered an uncommon disease in Japan because PA(pernicious anemia)and gastric type I NET are less frequent in Japan compared to western countries. Recently, diagnoses of type A gastritis by endoscopic gastric cancer examinations are increasing. Our study aims to elucidate the clinical characteristics of patients with type A gastritis from our institute. Type A gastritis was defined by reversed gastric mucosal atrophy observed during endoscopy and the presence of anti-parietal cell, anti-intrinsic factor antibodies, enterochromaffin-like hyperplasia, or ECM(endocrine cell micronests).

 Forty-seven patients(20 men, 27 females ; mean age 64.4 years, range 3-89 years)were diagnosed with type A gastritis in this study. PA was present in seven patients(14.9%), and eight patients(17.0%)had autoimmune disease(five chronic thyroiditis, three Graves' disease, and one type I diabetes mellitus, including duplication). Six patients were diagnosed with Gastric NET, and six were diagnosed with adenocarcinoma(12.8%)(five early stage and one advanced). Thirty-six patients(87.8%, 36/41)were positive for anti-parietal cell antibodies, and 12 patients(41.4%, 12/29)were positive for anti-intrinsic factor antibodies. ECM of corpus mucosa was detected in 22 patients(71.0%, 22/31). The mean serum gastrin level was 2,930.0±1,849.8pg/mL and the mean PG I level was 6.6±4.1ng/mL. Four patients(8.9%, 4/45)were positive for Helicobacter pylori infection.

Copyright © 2019, Igaku-Shoin Ltd. All rights reserved.


54巻7号 (2019年6月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院