Biological Behavior of Gastric Low-grade Carcinoma with Gastric Mucin Phenotype Yasuharu Kaizaki 1 , Hiroyuki Aoyagi 2 , Kenkei Hasatani 2 , Tamon Miyanaga 3 , Toshiyuki Okuda 3 , Kenji Dohden 3 , Masakazu Hattori 3 , Toshie Hara 1 , Akiya Kogami 1 1Department of Pathology, Fukui Prefectural Hospital, Fukui, Japan 2Department of Gastroenterology, Fukui Prefectural Hospital, Fukui, Japan 3Department of Surgery, Fukui Prefectural Hospital, Fukui, Japan Keyword: 低異型度胃癌 , 胃型形質 , 分化型胃癌 , 悪性度 pp.61-68
Published Date 2018/1/25
DOI https://doi.org/10.11477/mf.1403201260
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 To clarify the biological behavior of gastric low-grade carcinoma with gastric mucin phenotype, 13 cases with low-grade components infiltrated beyond the mucosa(low-grade group)and 8 cases with both low-and high-grade components infiltrated beyond the mucosa(partial low-grade group)were clinicopathologically examined. In the low-grade group, tumor size was small and tumor depth remained in the submucosal layer in most cases, and only 2 of the 13 cases were advanced carcinoma. However, lymphovascular invasion was observed in four cases, and cell proliferation ability was almost the same as that of an ordinary gastric carcinoma. With respect to prognosis, one patient with peritoneal dissemination in the low-grade group died. In the partial low-grade group, two patients with peritoneal dissemination and one with liver metastasis died. Gastric low-grade carcinoma with gastric mucin phenotype has poor infiltration tendency, and the prognosis in most cases is good. Therefore, we concluded that prognosis in cases with deep invasion is equivalent to that in ordinary advanced carcinoma.

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