Differentiated Adenocarcinoma of the Gastric and Intestinal Phenotype―Histological Appearance and Biological Behavior Eisaku Ito 1 , Touichiro Takizawa 1 1Department of Human Pathology, Tokyo Medical and Dental University, School of Medicine Keyword: 分化型胃癌 , 形質発現 , 悪性度 , 組織型 pp.701-706
Published Date 2003/4/25
DOI https://doi.org/10.11477/mf.1403100863
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 To investigate its relationship with histology and clinicopathologic factors, differentiated gastric carcinomas with submucosal invasion were classified into simplified gastric phenotype(sG-type), simplified intestinal phenotype(sI-type)and Null phenotype(N-type).

 As a result, in papillary adenocarcinoma, the number of sG-type cases was significantly higher than that of sI-type cases. The incidence of lymph node metastasis in papillary adenocarcinoma(44 %)was apparently higher than that of tubular adenocarcinoma(6 %). In papillary adenocarcinoma, the incidence of lymphatic and venous invasion of sG-type carcinoma was higher than that of sI-type carcinoma. However, the difference in the incidence of lymph node metastasis between them was not significant. We encountered a case of papillary adenocarcinoma of intestinal phenotype with submucosal invasion, which lacked lymph node metastasis. About 1 year after the operation, the patient died of multiple liver metastasis. In tubular adenocarcinoma, there was no significant difference in the lymph node metastatic rate and the lymphatic and venous invasion rate between each phenotype. Needless to say, sG-type papillary adenocarcinoma cases included a relatively high degree of malignant cases. However, to investigate the difference of biological behavior and malignancy in differentiated adenocarcinoma from the viewpoint of its phenotype, future examination including postoperative long-term follow-up of cases is required.

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