Companion Diagnostics for Gastrointestinal Cancer Akiko Nagatsuma 1 , Atsushi Ochiai 1 1Division of Biomarker Discovery, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan Keyword: コンパニオン診断 , HER2 , 胃癌 , 腫瘍内不均一 pp.1085-1091
Published Date 2017/7/25
DOI https://doi.org/10.11477/mf.1403201131
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 Companion diagnostics is an important tool for selecting patients with cancer who are most likely to clinically benefit from a particular molecular-targeted drug. This report focuses on the companion diagnostics for HER2-overexpressing gastric cancer. Intra-tumor heterogeneity in gastric cancer is an important phenomenon, so we need to recognize that reported HER2 status represents only a fraction of gastric cancer tissue. For accurate immunohistochemical diagnosis of gastric cancer using formalin-fixed, paraffin-embedded blocks, each process for sample preparation, fixation and storage need to be appropriate.

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