Stomach and Intestine(Tokyo) Volume 51, Issue 10 (September 2016)

Pathological Risk Factors for the Recurrence or Metastasis of Superficial Barrett's Carcinoma Junko Aida 1 , Tatsuro Ishizaki 2 , Toshiyuki Ishiwata 1 , Kaiyo Takubo 1 , Tomio Arai 3 1Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 2Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo 3Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo Keyword: 表在型Barrett癌 , 再発・転移危険因子 , low-risk , 内視鏡的切除 , リンパ節転移 pp.1269-1282
Published Date 2016/9/25
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 Endoscopic therapy is often used for superficial Barrett's carcinoma(BC). However, there is an urgent need to clarify the risk factors possibly involved in recurrence or metastasis. In this report, we address a range of potential risk factors on the basis of clinicopathological reports from Western countries and discuss the results of a questionnaire survey conducted by us.

 For Western populations, the criteria for“low-risk”superficial BC include a tumor size of ≦20mm, an intramucosal location, a well-to-moderately differentiated histology, and absence of lymphovascular invasion. Our data were mostly concordant with these risk factors.

 Many existing reports have indicated that submucosal cancers invasive to the superficial submucosal layer are curable if no risk factors other than depth are evident. Our present data indicated that many submucosal cases had no risk factors and were completely curable. As a benchmark for classification into“SM1”and“SM2”, 500μm is considered to be more suitable than 200μm.

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51巻10号 (2016年9月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院