Gastric Ulcers with Neither Helicobacter pylori Infection nor Non-steroidal Anti-inflammatory Drugs Takeshi Kanno 1,2 , Katsunori Iijima 3 , Tomoyuki Koike 1 , Waku Hatta 1 , Nobuyuki Ara 1 , Kiyotaka Asanuma 1 , Naoki Asano 1 , Akira Imatani 1 , Tooru Shimosegawa 1 1Department of Gastroenterology, Tohoku University Hospital, Sendai, Japan 2Graduate Medical Education Center, Tohoku University Hospital, Sendai, Japan 3Department of Gastroenterology, Akita University Hospital, Akita, Japan Keyword: Helicobacter pylori , 災害時ストレス , 動脈硬化性疾患 , 難治性 , 易再発性 pp.900-906
Published Date 2017/6/25
DOI https://doi.org/10.11477/mf.1403201104
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 Peptic ulcers caused neither by Helicobacter pylori infection nor by nonsteroidal anti-inflammatory drugs are termed as IPU(idiopathic peptic ulcers)and show a 12% prevalence rate among Japanese patients with peptic ulcers. Based on the research after the 2011 Great East Japan earthquake, psychological stress during large-scale disasters is newly recognized as an independent risk factor for peptic ulcers.

 When not experiencing a disaster, IPUs are ordinary clinical situations, possibly having the following features:1)underlying comorbid arteriosclerosis, particularly in the antrum of the stomach, often showing refractoriness and 2)a high recurrence rate. Differences between H. pylori-unrelated IPUs and IPUs after eradication therapy of H. pylori are still unclear, and additional large-scale studies are needed for clarification.

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