Intractable Peptic Ulcer after Successful Eradication of Helicobacter pylori Hitoshi Sekine 1 , Shuichi Ohara 1 , Kouichi Sugiyama 1 , Akira Imatani 1 , Toru Shimosegawa 1 1Department of Gastroenterology, Division of Internal Medicine, Tohoku University Graduate School of Medicine Keyword: Helicobacter pylori , 除菌療法 , 難治性潰瘍 pp.505-510
Published Date 2002/3/25
DOI https://doi.org/10.11477/mf.1403103484
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 We examined endoscopically the healing of gastric and duodenal ulcers after Helicobacter pylori eradication (GU 228 cases and DU 239 cases). In five patients, gastric ulcers were unhealed for more than five months after eradication. Four of those five patients had proximal gastric ulcers. The characteristic appearance of the ulcers was unevenness surrounding elevated mucosa, rigidity, and greater depth. One of those patients had a lansoprazole-refractory ulcer as shown by the absorption disturbance of lansoprazole. Two patients were treated with lansoprazole 60 mg/day for 16 weeks, resulting in the healing of their ulcers, but the ulcers recurred again in a short period despite acid suppressive therapy using histamin2 receptor antagonist (H2-RA). Another two patients were treated with H2-RA, and the ulcers became worse temporarily.

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