The Histological Features of Gastric Ulcers Resected Cases in the Past and New Causes of Ulcers Atsuko Ota 1 , Akinori Iwashita 1 , Hiroshi Tanabe 1 , Kenta Chuman 1,2 , Rino Yamaoka 1,2 1Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan 2Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan Keyword: 胃潰瘍 , Helicobacter pylori胃炎 , 薬剤起因性潰瘍 , NSAIDs pp.868-875
Published Date 2017/6/25
DOI https://doi.org/10.11477/mf.1403201100
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 We analyzed 15 cases of resected gastric ulcers in our hospital and obtained the following results:(1)The number of resected gastric ulcer cases has clearly decreased in the last 30 years ; (2)Gastric ulcers mainly occurred in older men, and patients with deep ulcers, graded as Ul-IV, accounted for 77.8% of all cases ; (3)According to the histological findings of the background gastric mucosa, it was suspected that most cases demonstrating chronic active gastritis were associated with Helicobacter pylori(H. pylori)infection, but only 40% of all the cases showed the presence of H. pylori ; and(4)On histological examination, two cases who received eradication therapies revealed no neutrophilic infiltration without atrophy and only a mild chronic inflammatory cell infiltration. The number of patients with drug-induced gastrointestinal ulcers, such as those induced by NSAIDs(nonsteroidal anti-inflammatory drugs), has been increasing in recent years. We described the histology of NSAID-induced ulcers and the histological changes in gastric mucosa due to proton pump inhibitor treatment.

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