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Japanese

Localized Amyloidosis of the Rectum Presenting as a Depressed Lesion, Report of a Case Koji Takahashi 1 , Hidetoshi Aoki 1 , Mitsuyasu Yano 1 , Hiroyoshi Yoshikawa 1 , Keiko Mori 1 , Sayo Matsumoto 1 , Kanako Otsuka 1 , Shinya Hayashi 1 , Toshihiro Omoya 1 , Kenichi Kitazoe 1 , Yasuhiro Suzuki 1 , Hiroshi Shibata 1 , Nobuo Satake 2 , Eiji Kudo 2 1Department of Gastroenterology, Tokushima Prefectural Central Hospital, Tokushima, Japan 2Department of Pathology, Tokushima Prefectural Central Hospital, Tokushima, Japan Keyword: アミロイドーシス , 大腸 , 限局性 , 陥凹性病変 pp.831-839
Published Date 2017/5/25
DOI https://doi.org/10.11477/mf.1403201090
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 A man in his 70s with rectal abnormalities detected on colonoscopy was referred to our hospital. A relatively well-defined, red-colored, round-shaped, depressed lesion was recognized in the rectum ; insular mucosa and blood vessels surrounding the colonic glands were observed to be normal using magnifying narrow-band imaging, and the first three layers exhibited an almost uniform high-echoic lesion on endoscopic ultrasonography. Biopsy of the lesion confirmed amyloidosis, with no amyloid deposits in the gastrointestinal tract other than those in the depressed lesion in the rectum. Cardiac and thyroid ultrasounds revealed no findings suggestive of amyloidosis, and there were no abnormal findings in the bone marrow analysis. Detection of amyloid A(−)by immunostaining, transthyretin(−), β2-microglobulin(−), and an indeterminable level of κ or λ immunoglobulin light chain led to the diagnosis of localized amyloidosis in the rectum. The patient is being followed up with no intervention. Here we report a very rare case of amyloid deposits found only in a depressed lesion in the rectum.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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