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Clinicopathological Characteristics of Colorectal Endocrine Cell Carcinoma Mari Shimada 1 , Yasuharu Kaizaki 2 , Chikashi Hiranuma 1 , Kenji Dohden 1 , Masakazu Hattori 1 , Yasuo Hashizume 1 1Department of Surgery, Fukui Prefectural Hospital, Fukui, Japan 2Department of Pathology, Fukui Prefectural Hospital, Fukui, Japan Keyword: 大腸内分泌細胞癌 , NEC , 術前診断能 pp.423-429
Published Date 2017/4/25
DOI https://doi.org/10.11477/mf.1403200870
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 We investigated 18 patients with colorectal endocrine cell carcinoma who were treated at our hospital between 2001 and 2015. The patients had either type 2 or 3 thick, ulcerogenic tumors with carcinoma components in the deep regions of tumors and ulcer floors. Although undifferentiated carcinoma components were found on biopsy in many of the patients, a preoperative diagnosis on the basis of biopsy was considered difficult in some patients because of their disease stage at diagnosis or the percentage of adenocarcinoma cells. Clinicopathological characteristics and prognoses did not reveal any difference in the amount of endocrine cell carcinoma components in the patients' tumors. The prognosis of the disease was poor regardless of the amount of endocrine cell carcinoma components. Multidisciplinary treatment approaches have been recently attempted for improving the prognosis ; a preoperative diagnosis is considered important in deciding treatment courses. Examinations should be performed with colorectal endocrine cell carcinoma in mind when undifferentiated carcinoma components are found on biopsy or a tendency of deep infiltration is suggested.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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