Pathological Characteristics of Endocrine Cell Tumor of the Upper Gastrointestinal Tract Yasuharu Kaizaki 1 , Osamu Hosokawa 2 , Yoshihide Asaumi 3 , Tamon Miyanaga 3 , Kenji Dohden 3 , Masakazu Hattori 3 , Yasuo Hashizume 3 , Hiroyuki Aoyagi 4 , Naoyuki Ibe 4 , Kouji Urasaki 1 1Department of Pathology, Fukui Prefectural Hospital, Fukui, Japan 2Department of Surgery, Yokohama Sakae Kyosai Hospital, Yokohama, Japan 3Department of Surgery, Fukui Prefectural Hospital, Fukui, Japan 4Department of Gastroenterology, Fukui Prefectural Hospital, Fukui, Japan Keyword: 内分泌細胞腫瘍 , 上部消化管 , カルチノイド , 内分泌細胞癌 , NET pp.957-970
Published Date 2013/6/25
DOI https://doi.org/10.11477/mf.1403113853
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 Endocrine cell tumor is classified as carcinoid tumor with slow growth and ECC(endocrine cell carcinoma)has rapid growth and poor prognosis. For the upper gastrointestinal tract, carcinoid tumors in the esophagus and ECCs in the duodenum are extremely rare. ECC of the esophagus and carcinoid tumors of the duodenum are sometimes encountered. Gastric carcinoid tumor is classified into three types according to the difference in the developmental mechanism : Type I, associated with autoimmune chronic atrophic gastritis ; Type II, associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome ; Type III, sporadic. There are noticeable differences in their pathological and biological characteristics. Most gastric ECCs arises from adenocarcinoma. They indicate at a high rate of metastasis and have a worse prognosis than ordinary adenocarcinomas. Recently, the WHO classification of gastroenteropancreatic neuroendocrine tumor focused on the Ki-67 index. This classification has been published and spread rapidly. But, Ki-67 is only one of the biological factors of endocrine cell tumors and it is not intended to be applied to connecting separate types of carcinoid tumors and ECC. So, for endocrine cell tumors, we should make a diagnosis based on tumor origin.

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