Recent Advances and Future Perspectives of Colon Capsule Endoscopy Shiro Oka 1,2 , Shinji Tanaka 1,2 , Sayoko Kunihara 2 , Atsushi Igawa 2 , Makoto Nakano 2 , Kazuaki Chayama 2 1Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan 2Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan Keyword: 大腸カプセル , 前処置 , 診断能 , 将来展望 pp.872-880
Published Date 2016/6/25
DOI https://doi.org/10.11477/mf.1403200661
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 Conventional colonoscopy is the gold standard for diagnostic examination of the colon. However, the overall acceptance of this procedure is low due to patients' fear of complications or embarrassment. With the advanced technology used in PillCam® CCE2(COLON 2 capsule endoscopy), there have been marked improvements in diagnostic rates for CCE2 with regard to the detection of colonic polyps and colorectal cancer. CCE2 represents a minimally invasive, patient-friendly procedure that offers complete visualization of the colon and rectum. The acceptability of CCE2-based examination is extremely high. Patients with a previously failed colonoscopy could be offered CCE2 examination as an optional procedure. There is low-quality evidence that CCE2 has good sensitivity and specificity for detecting colorectal polyps. In fact, low-quality evidence does not show a difference in accuracy between CCE2 and computed tomography colonography. There is also low-quality evidence that CCE2 has a good safety profile with few associated adverse events. CCE2 is a safe and effective means of detecting colorectal cancer and polyps in screening-positive cohorts(those with a positive fecal immunological test)and has the potential to reduce the number of optical colonoscopies. In addition, examination is limited not only to the colon, but also enables the detection of clinically relevant manifestations in other parts of the GI tract. Therefore, entire GI tract evaluation using CCE2 may be possible in the near future.

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