Clinicopathological Features of Gastric Adenocarcinoma of Fundic Gland Type:Focusing on Radiographic and Endoscopic Findings Hiroki Yaita 1 , Koichi Kurahara 1 , Yumi Oshiro 2 , Keisuke Kawasaki 1,3 , Hirofumi Abe 1 , Shuji Kochi 1 , Tomohiro Nagasue 1 , Nobuaki Kuno 1 , Akira Harada 1 , Masashi Kameda 1 , Takahide Tanaka 1 , Kazuhide Iwasaki 1 , Ikuo Takahashi 4 , Minako Hirahashi 5 , Takashi Yao 6 , Tadahiko Fuchigami 1 1Division of Gastroenterology, Matsuyama Red cross Hospital, Matsuyama, Japan 2Department of Pathology, Matsuyama Red cross Hospital, Matsuyama, Japan 3Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan 4Division of Surgery, Matsuyama Red cross Hospital, Matsuyama, Japan 5Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan 6Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo Keyword: 胃底腺型胃癌 , H. pylori陰性胃癌 , H. pylori感染 , 内視鏡的萎縮 , 分化型胃癌 pp.1493-1506
Published Date 2015/11/25
DOI https://doi.org/10.11477/mf.1403200466
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 To elucidate the clinicopathological features of GA-FG(gastric adenocarcinoma of fundic gland type), we retrospectively investigated resected gastric cancers. Among 1,305 patients who had been treated by endoscopic resection or surgery, nine(0.7%)had GA-FG : five(55.6%)negative for Helicobacter pylori(H. pylori)infection and four(44.4%)with past H. pylori infection. Most GA-FGs occurred in the upper/middle region of the stomach, seen as a 0-IIa/0-IIc lesion with vascular ectasia and a faded tumor surface. In 85.7% of GA-FGs, endoscopic ultrasonography detected a hypoechoic lesion between the deep layer of the mucosa and the submucosa. In addition, 14 of 1,305 patients(1.07%)had H. pylori-negative gastric cancer, five of whom had GA-FG(35.7%). Further epidemiological studies are warranted to better elucidate the clinicopathological features of GA-FG.

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