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要旨 ESDが施行されたH. pylori陰性の背景胃粘膜に発生した未分化型早期胃癌の特徴について検討した.H. pylori陰性の定義は,除菌歴なし,切除ESD標本に炎症所見なし,上部消化管内視鏡検査にて萎縮なし,RAC陽性,呼気テスト陰性,H. pylori抗体3U/ml以下,ペプシノーゲン陰性とし,すべてがそろった35症例,36病変を対象とした.男女比は19:16,組織型はsignet-ring cell carcinoma 35病変,poorly differentiated adenocarcinomaが1病変であった.深達度は全例Mで,大きさの平均は7.4mmであった.肉眼型は0-IIc型が30病変,0-IIb型が6病変,色調は褪色調が33病変,発赤調が3病変であった.粘膜内病変36例の粘膜内での増殖形式は,粘膜中層にとどまるものが13病変,中~上層が22病変,中~下層が1病変であった.背景は胃底腺領域が25病変,腺境界が5病変,幽門腺領域が6病変であった.ESD症例からみたH. pylori陰性未分化型早期胃癌の頻度は2.3%であった.頻度は低いが今後H. pylori陰性化時代に向けて注意すべき病変と考えられた.
We examined 35 cases(19 males and 16 females)with 36 lesions of Helicobacter pylori(H. pylori)-negative early gastric undifferentiated adenocarcinoma. All cases had no history of H. pylori eradication, no inflammatory changes on the resected specimen, and no sign of atrophy on endoscopy, with negative results for pepsinogen and urea breath tests. Of the 36 lesions, 35 were diagnosed as signet-ring cell carcinoma, with only 1 case of poorly differentiated adenocarcinoma. The mean lesion size was 7.4mm. The macroscopic type was 0-IIc in 30 lesions and 0-IIb in 6 lesions. The depth classification was M in 36 lesions. Of the 36 intramucosal lesions, 13 were limited to the proliferative zone, 22 invaded from the proliferative zone to the upper side, and only 1 invaded the lower mucosa. With respect to the background mucosa, 25 lesions originated from the fundic gland area, 5 originated from the intermediate zone, and 6 originated from the pyloric glands. The incidence of HP-N-UDEGC was 2.3%of all ESD cases. These cases may have considerable relevance in the near future.
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